The Alu sequence is inserted into a noncoding region of the PV92 locus on chromosome 16 and is not related to a particular disease, nor does it code for any protein sequence. It is simply a DNA sequence that can be used to study human genotypic frequencies. Because Alu repeats appear in the general population at random, the Alu insert in chromosome 16 is very useful for the study of gene frequencies in localized human populations. Theoretically, in some small, geographically isolated populations, all
individuals may be homozygous +/+. In others, the individuals may all be homozygous –/–. In a “melting-pot” population, the three genotypes (+/+, +/–, –/–) may exist in equilibrium.
individuals may be homozygous +/+. In others, the individuals may all be homozygous –/–. In a “melting-pot” population, the three genotypes (+/+, +/–, –/–) may exist in equilibrium.
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